Phytopharmaceutical treatment of anxiety, depression, and dementia in the elderly: evidence from randomized, controlled clinical trials.
Total years in practice: 3
June 19, 2015
Wien Med Wochenschr. 2015 Jun 20. Epub 2015 Jun 20. PMID: 26092515
Anxiety Disorders, Dementia, Depression
Herbal Therapy, Holistic Medicine
Based on subgroup analyses of randomized, controlled clinical trials, we review the efficacy of three phytopharmaceutical drugs, respectively of the corresponding active substances silexan® (WS® 1265, lavender oil) in anxiety disorders, WS® 5570 (Hypericum extract) in major depression, and EGb 761® (Ginkgo biloba extract) in Alzheimer, vascular, or mixed type dementia, in elderly patients aged ??60 years.Four trials were eligible in each indication. Meta-analyses and analysesbased on pooled raw data showed that the three drugs were significantly superior to placebo in the elderly subset, and that their treatment effects reflected in the main outcome measures (Hamilton Anxiety scale, Hamilton Depression scale, Neuropsychiatric Inventory) were comparable with those observed in the original trials without age restrictions.The results confirm the efficacy of the three herbal active substances in elderly patients of ??60 years of age. In anxiety, depression, and dementia, they thus represent efficacious and well-tolerated alternatives to synthetic drugs.
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